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~ Coccidiosis Infestations ~

Discussion in 'Health & Nutrition' started by Your Worst Nightmare, May 7, 2004.

  1. wicked13

    wicked13 Top Dog

    Thanks appreciate the help
  2. slim12

    slim12 CH Dog Staff Member

    Sulfadimethoxine 12 1/2% solution

    Sulmet brand is no longer offered. What are the substitutions?

  3. Vicki

    Vicki Administrator Staff Member


    .2cc per 1 pound of body weight

    Product Description

    TOLTRAZURIL Oral Suspension 5% is the result of the research efforts to help treat EPM. Due to its characteristics, TOLTRAZURIL represents a new standard in coccidiosis control in Racehorses, Camels, Pigeons, Dogs, Greyhounds and Alpacas.

    TOLTRAZURIL Oral Suspension 5% belongs to the chemical group of symmetric triazinons and is not chemically related to any other anticoccidial drug that is currently used in veterinary medicine. TOLTRAZURIL Oral Suspension 5% is a 5% solution. Due to its particular mode of action, which affects all intracellular structures of Coccidia, TOLTRAZURIL Oral Suspension 5% demonstrates extremely high efficacy, as shown by the following benefits:

    *stops oocyst shedding

    *prevents or reduces the severity of lesions
    *improves growth rate
    *improves feed conversion

    These product characteristics make TOLTRAZURIL Oral Suspension 5% suitable for both metaphylaxis and therapy in domesticated animals.

    TOLTRAZURIL Oral Suspension 5% represents an extremely important tool in the control of coccidia problems.

    TOLTRAZURIL Oral Suspension 5% damages all intracellular development stages of Eimeria (Coccidia).

    TOLTRAZURIL Oral Suspension 5% affects schizonts, micro- and macrogametes, but not the tissue cells of the host animals as was shown in light and electron microscopic studies.

    These findings suggest that TOLTRAZURIL Oral Suspension 5% interferes with the division of the nucleus and with the activity of the mitochondria which is responsible for the respiratory metabolism of Coccidia.

    In the magrometes, TOLTRAZURIL Oral Suspension 5% damages the so-called wall-forming bodies. In all intracellular developmental stages, severe vacuolisation occurs due to inflation of the endoplasmatic reticulum. Therefore, TOTRAZURIL has a coccidiocidal mode of action. The special mode of action results in the following advantages:

    *TOLTRAZURIL Oral Suspension 5% acts on all intracellular developmental stages
    *TOLTRAZURIL Oral Suspension 5% does not interfere with the development of immunity
    *follow-up treatment usually is not necessary,
    *even an advanced infection (after 3-5 days) gametogony can still be treated successfully,
    *the efficacy of TOLTRAZURIL Oral Suspension 5% is independent to the severity of the infection.

    For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine, camels, alpacas and pigeons. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

  4. Forever-So REAL

    Forever-So REAL 5x Grand Champion (25xW) Premium Member

    Coccidia of the genus Cystoisospora cause mild to severe diarrhoea in dogs. The effects of toltrazuril treatment on cystoisosporosis were studied under experimental and field conditions. Twenty-four puppies were experimentally infected each with 4 x 10(4) oocysts of the Cystoisospora ohioensis group. Three groups of six puppies were treated 3 dpi with 10, 20 or 30 mg/kg body weight of toltrazuril suspension (5%); the remaining six puppies served as non-treated controls. Toltrazuril suspension or microgranulate were given once in a dose of 10 or 20 mg/kg body weight, respectively, to naturally infected puppies in conventional dog breeding facilities, depending on the coproscopical evidence of infection. Oocyst excretion and clinical data were recorded.

    Under experimental conditions, the non-treated puppies excreted oocysts beginning at 6 dpi and suffered from catarrhalic to haemorrhagic diarrhoea. On 12 dpi, four of six non-treated puppies died. Irrespective of the dose, toltrazuril treatment totally suppressed oocyst excretion and no diarrhoea or other signs of disease were observed in the treated groups. Natural Cystoisospora infections were regularly found during the 3rd or 4th week of age in dog breeding facilities although not always associated with diarrhoea. A single oral application of toltrazuril abrogated oocyst shedding and the treated puppies remained generally coproscopically negative during the following 2-4 weeks.

    Cystoisospora is pathogenic for puppies and can induce severe disease. Natural infections are common in conventional dog breeding facilities. Toltrazuril treatment is suitable for controlling cystoisosporosis under experimental and field conditions. A single oral treatment for puppies in the 3rd/4th week of age is recommended.”

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